Dr. Gazzinelli-Guimaraes’ research program has been focused on the regulation of the immune response to helminth parasitic infections and to the pathogenesis of allergic diseases. The Gazzinelli Lab has a specific interest in understanding the plasticity and specificity of circulating peripheral and tissue-resident effector Th2 cells driven by helminth antigens and/or allergens, as well as to understand the role of the effector Th2 subsets in the establishment of tissue Type-2-mediated inflammation using both mouse models and human studies. These studies aim to identify potential targets for the development of selective immunotherapy that could prevent chronic helminth infection or that could diminish allergic inflammation.
